                         SEQUENCE LISTING

<110>  Yale University
       STRITTMATTER, Stephen M.
       HUANG, Henry
 
<120>  Reactivation of Axon Growth and Recovery in Chronic Spinal Cord 
       Injury

<130>  2681.050PC01/SAC/JBF

<150>  US 61/069,233
<151>  2008-03-13

<160>  31    

<170>  PatentIn version 3.3

<210>  1
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  1

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  2

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  3
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  3

Glu Ser Gly Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  4

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr 
1               5                   10                  


<210>  5
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  5

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Ser Thr Gln 
1               5                   10                  15  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  6

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  7
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  7

Gly Ser Thr Ser Gly Ser Gly Lys Ser Ser Glu Gly Lys Gly 
1               5                   10                  


<210>  8
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  8

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  9
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker

<400>  9

Glu Ser Gly Ser Val Ser Ser Glu Glu Leu Ala Phe Arg Ser Leu Asp 
1               5                   10                  15      


<210>  10
<211>  473
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Arg Ala Ser Ala Gly Gly Ser Arg Leu Leu Ala Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Gln Val Ala Ala Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Val Gly Ile Pro Ala Ala Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Arg Ala Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Val Leu Ala Arg Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu Arg Ser Val Asp Pro Ala Thr Phe His Gly 
        115                 120                 125             


Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Ala Leu Gln Ala Leu Pro Asp Asp Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Ser Ser 
            180                 185                 190         


Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn Arg Val Ala His Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Ala 
225                 230                 235                 240 


Leu Pro Thr Glu Ala Leu Ala Pro Leu Arg Ala Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Ser 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Ala Asn 
    290                 295                 300                 


Asp Leu Gln Gly Cys Ala Val Ala Thr Gly Pro Tyr His Pro Ile Trp 
305                 310                 315                 320 


Thr Gly Arg Ala Thr Asp Glu Glu Pro Leu Gly Leu Pro Lys Cys Cys 
                325                 330                 335     


Gln Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly Arg Pro 
            340                 345                 350         


Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp Ser 
        355                 360                 365             


Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro Phe 
    370                 375                 380                 


Gly Thr Leu Pro Gly Ser Ala Glu Pro Pro Leu Thr Ala Val Arg Pro 
385                 390                 395                 400 


Glu Gly Ser Glu Pro Pro Gly Phe Pro Thr Ser Gly Pro Arg Arg Arg 
                405                 410                 415     


Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu Gly 
            420                 425                 430         


Gln Ala Gly Ser Gly Gly Gly Gly Thr Gly Asp Ser Glu Gly Ser Gly 
        435                 440                 445             


Ala Leu Pro Ser Leu Thr Cys Ser Leu Thr Pro Leu Gly Leu Ala Leu 
    450                 455                 460                 


Val Leu Trp Thr Val Leu Gly Pro Cys 
465                 470             


<210>  11
<211>  473
<212>  PRT
<213>  Rattus

<400>  11

Met Lys Arg Ala Ser Ser Gly Gly Ser Arg Leu Leu Ala Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Arg Val Ala Thr Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Thr Gly Ile Pro Ala Ser Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser Tyr Val Pro Ala Ala Ser Phe Gln Ser Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Ala Leu Ala Gly Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Thr Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu Arg Val Val Asp Pro Thr Thr Phe Arg Gly 
        115                 120                 125             


Leu Gly His Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Asn Leu Gln Ala Leu Pro Asp Asn Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Pro Ser 
            180                 185                 190         


Val Pro Glu His Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn His Val Ala Arg Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Met 
225                 230                 235                 240 


Leu Pro Ala Glu Val Leu Val Pro Leu Arg Ser Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Asn 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Ala Ser 
    290                 295                 300                 


Asp Leu Glu Gly Cys Ala Val Ala Ser Gly Pro Phe Arg Pro Phe Gln 
305                 310                 315                 320 


Thr Asn Gln Leu Thr Asp Glu Glu Leu Leu Gly Leu Pro Lys Cys Cys 
                325                 330                 335     


Gln Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly Arg Pro 
            340                 345                 350         


Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp Thr 
        355                 360                 365             


Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro Phe 
    370                 375                 380                 


Gly Thr Leu Pro Gly Ser Ala Glu Pro Pro Leu Thr Ala Leu Arg Pro 
385                 390                 395                 400 


Gly Gly Ser Glu Pro Pro Gly Leu Pro Thr Thr Gly Pro Arg Arg Arg 
                405                 410                 415     


Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu Gly 
            420                 425                 430         


Gln Ala Gly Ser Gly Ser Ser Gly Thr Gly Asp Ala Glu Gly Ser Gly 
        435                 440                 445             


Ala Leu Pro Ala Leu Ala Cys Ser Leu Ala Pro Leu Gly Leu Ala Leu 
    450                 455                 460                 


Val Leu Trp Thr Val Leu Gly Pro Cys 
465                 470             


<210>  12
<211>  473
<212>  PRT
<213>  Mus

<400>  12

Met Lys Arg Ala Ser Ser Gly Gly Ser Arg Leu Leu Ala Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Arg Val Ala Thr Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Thr Gly Ile Pro Ala Ser Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Gln Ser Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Ala Leu Ala Arg Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Thr Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu His Val Val Asp Pro Thr Thr Phe His Gly 
        115                 120                 125             


Leu Gly His Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Arg Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Asn Leu Gln Ala Leu Pro Asp Asn Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Pro Ser 
            180                 185                 190         


Val Pro Glu His Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn His Val Ala Arg Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Met 
225                 230                 235                 240 


Leu Pro Ala Glu Val Leu Met Pro Leu Arg Ser Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Asn 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Asp Arg Asp Leu Lys Arg Leu Ala Ala Ser 
    290                 295                 300                 


Asp Leu Glu Gly Cys Ala Val Ala Ser Gly Pro Phe Arg Pro Ile Gln 
305                 310                 315                 320 


Thr Ser Gln Leu Thr Asp Glu Glu Leu Leu Ser Leu Pro Lys Cys Cys 
                325                 330                 335     


Gln Pro Asp Ala Ala Asp Lys Ala Ser Val Leu Glu Pro Gly Arg Pro 
            340                 345                 350         


Ala Ser Ala Gly Asn Ala Leu Lys Gly Arg Val Pro Pro Gly Asp Thr 
        355                 360                 365             


Pro Pro Gly Asn Gly Ser Gly Pro Arg His Ile Asn Asp Ser Pro Phe 
    370                 375                 380                 


Gly Thr Leu Pro Ser Ser Ala Glu Pro Pro Leu Thr Ala Leu Arg Pro 
385                 390                 395                 400 


Gly Gly Ser Glu Pro Pro Gly Leu Pro Thr Thr Gly Pro Arg Arg Arg 
                405                 410                 415     


Pro Gly Cys Ser Arg Lys Asn Arg Thr Arg Ser His Cys Arg Leu Gly 
            420                 425                 430         


Gln Ala Gly Ser Gly Ala Ser Gly Thr Gly Asp Ala Glu Gly Ser Gly 
        435                 440                 445             


Ala Leu Pro Ala Leu Ala Cys Ser Leu Ala Pro Leu Gly Leu Ala Leu 
    450                 455                 460                 


Val Leu Trp Thr Val Leu Gly Pro Cys 
465                 470             


<210>  13
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys Arg Ala Ser Ala Gly Gly Ser Arg Leu Leu Ala Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Gln Val Ala Ala Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Val Gly Ile Pro Ala Ala Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Arg Ala Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Val Leu Ala Arg Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu Arg Ser Val Asp Pro Ala Thr Phe His Gly 
        115                 120                 125             


Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Ala Leu Gln Ala Leu Pro Asp Asp Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Ser Ser 
            180                 185                 190         


Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn Arg Val Ala His Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Ala 
225                 230                 235                 240 


Leu Pro Thr Glu Ala Leu Ala Pro Leu Arg Ala Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Ser 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Ala Asn 
    290                 295                 300                 


Asp Leu Gln Gly Cys Ala Val Ala Thr Gly Pro Tyr His Pro Ile Trp 
305                 310                 315                 320 


Thr Gly Arg Ala Thr Asp Glu Glu Pro Leu Gly Leu Pro Lys Cys Cys 
                325                 330                 335     


Gln Pro Asp Ala Ala Asp Lys Ala 
            340                 


<210>  14
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Arg Ala Ser Ala Gly Gly Ser Arg Leu Leu Ala Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Gln Val Ala Ala Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Val Gly Ile Pro Ala Ala Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Arg Ala Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Val Leu Ala Arg Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu Arg Ser Val Asp Pro Ala Thr Phe His Gly 
        115                 120                 125             


Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Ala Leu Gln Ala Leu Pro Asp Asp Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Ser Ser 
            180                 185                 190         


Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn Arg Val Ala His Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Ala 
225                 230                 235                 240 


Leu Pro Thr Glu Ala Leu Ala Pro Leu Arg Ala Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Ser 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Ala Asn 
    290                 295                 300                 


Asp Leu Gln Gly Cys Ala 
305                 310 


<210>  15
<211>  344
<212>  PRT
<213>  Rattus

<400>  15

Met Lys Arg Ala Ser Ser Gly Gly Ser Arg Leu Pro Thr Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Arg Val Ala Thr Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Arg Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Ala Gly Ile Pro Ala Ser Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser Tyr Val Pro Ala Ala Ser Phe Gln Ser Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Ala Leu Ala Gly Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Thr Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu Arg Val Val Asp Pro Thr Thr Phe Arg Gly 
        115                 120                 125             


Leu Gly His Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Asn Leu Gln Ala Leu Pro Asp Asn Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Pro Ser 
            180                 185                 190         


Val Pro Glu His Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn His Val Ala Arg Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Met 
225                 230                 235                 240 


Leu Pro Ala Glu Val Leu Val Pro Leu Arg Ser Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Gly Val Pro Ser Asn 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Thr Ser 
    290                 295                 300                 


Asp Leu Glu Gly Cys Ala Val Ala Ser Gly Pro Phe Arg Pro Phe Gln 
305                 310                 315                 320 


Thr Asn Gln Leu Thr Asp Glu Glu Leu Leu Gly Leu Pro Lys Cys Cys 
                325                 330                 335     


Gln Pro Asp Ala Ala Asp Lys Ala 
            340                 


<210>  16
<211>  310
<212>  PRT
<213>  Rattus

<400>  16

Met Lys Arg Ala Ser Ser Gly Gly Ser Arg Leu Pro Thr Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Arg Val Ala Thr Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Arg Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Ala Gly Ile Pro Ala Ser Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser Tyr Val Pro Ala Ala Ser Phe Gln Ser Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Ala Leu Ala Gly Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Thr Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu Arg Val Val Asp Pro Thr Thr Phe Arg Gly 
        115                 120                 125             


Leu Gly His Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Asn Leu Gln Ala Leu Pro Asp Asn Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Pro Ser 
            180                 185                 190         


Val Pro Glu His Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn His Val Ala Arg Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Met 
225                 230                 235                 240 


Leu Pro Ala Glu Val Leu Val Pro Leu Arg Ser Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Cys Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Gly Val Pro Ser Asn 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Thr Ser 
    290                 295                 300                 


Asp Leu Glu Gly Cys Ala 
305                 310 


<210>  17
<211>  310
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human NgR1 mutant

<400>  17

Met Lys Arg Ala Ser Ala Gly Gly Ser Arg Leu Leu Ala Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Gln Val Ala Ala Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Val Gly Ile Pro Ala Ala Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Arg Ala Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Val Leu Ala Arg Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu Arg Ser Val Asp Pro Ala Thr Phe His Gly 
        115                 120                 125             


Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Ala Leu Gln Ala Leu Pro Asp Asp Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Ser Ser 
            180                 185                 190         


Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn Arg Val Ala His Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Ala 
225                 230                 235                 240 


Leu Pro Thr Glu Ala Leu Ala Pro Leu Arg Ala Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Ala Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Ser 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Ala Asn 
    290                 295                 300                 


Asp Leu Gln Gly Ala Ala 
305                 310 


<210>  18
<211>  310
<212>  PRT
<213>  Rattus

<220>
<223>  Rat NgR1 mutant

<400>  18

Met Lys Arg Ala Ser Ser Gly Gly Ser Arg Leu Pro Thr Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Arg Val Ala Thr Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Arg Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Ala Gly Ile Pro Ala Ser Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser Tyr Val Pro Ala Ala Ser Phe Gln Ser Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Ala Leu Ala Gly Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Thr Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu Arg Val Val Asp Pro Thr Thr Phe Arg Gly 
        115                 120                 125             


Leu Gly His Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Asn Leu Gln Ala Leu Pro Asp Asn Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Pro Ser 
            180                 185                 190         


Val Pro Glu His Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn His Val Ala Arg Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Met 
225                 230                 235                 240 


Leu Pro Ala Glu Val Leu Val Pro Leu Arg Ser Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Ala Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Gly Val Pro Ser Asn 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Thr Ser 
    290                 295                 300                 


Asp Leu Glu Gly Ala Ala 
305                 310 


<210>  19
<211>  344
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Human NgR1 mutant

<400>  19

Met Lys Arg Ala Ser Ala Gly Gly Ser Arg Leu Leu Ala Trp Val Leu 
1               5                   10                  15      


Trp Leu Gln Ala Trp Gln Val Ala Ala Pro Cys Pro Gly Ala Cys Val 
            20                  25                  30          


Cys Tyr Asn Glu Pro Lys Val Thr Thr Ser Cys Pro Gln Gln Gly Leu 
        35                  40                  45              


Gln Ala Val Pro Val Gly Ile Pro Ala Ala Ser Gln Arg Ile Phe Leu 
    50                  55                  60                  


His Gly Asn Arg Ile Ser His Val Pro Ala Ala Ser Phe Arg Ala Cys 
65                  70                  75                  80  


Arg Asn Leu Thr Ile Leu Trp Leu His Ser Asn Val Leu Ala Arg Ile 
                85                  90                  95      


Asp Ala Ala Ala Phe Thr Gly Leu Ala Leu Leu Glu Gln Leu Asp Leu 
            100                 105                 110         


Ser Asp Asn Ala Gln Leu Arg Ser Val Asp Pro Ala Thr Phe His Gly 
        115                 120                 125             


Leu Gly Arg Leu His Thr Leu His Leu Asp Arg Cys Gly Leu Gln Glu 
    130                 135                 140                 


Leu Gly Pro Gly Leu Phe Arg Gly Leu Ala Ala Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Leu Gln Asp Asn Ala Leu Gln Ala Leu Pro Asp Asp Thr Phe Arg Asp 
                165                 170                 175     


Leu Gly Asn Leu Thr His Leu Phe Leu His Gly Asn Arg Ile Ser Ser 
            180                 185                 190         


Val Pro Glu Arg Ala Phe Arg Gly Leu His Ser Leu Asp Arg Leu Leu 
        195                 200                 205             


Leu His Gln Asn Arg Val Ala His Val His Pro His Ala Phe Arg Asp 
    210                 215                 220                 


Leu Gly Arg Leu Met Thr Leu Tyr Leu Phe Ala Asn Asn Leu Ser Ala 
225                 230                 235                 240 


Leu Pro Thr Glu Ala Leu Ala Pro Leu Arg Ala Leu Gln Tyr Leu Arg 
                245                 250                 255     


Leu Asn Asp Asn Pro Trp Val Cys Asp Ala Arg Ala Arg Pro Leu Trp 
            260                 265                 270         


Ala Trp Leu Gln Lys Phe Arg Gly Ser Ser Ser Glu Val Pro Cys Ser 
        275                 280                 285             


Leu Pro Gln Arg Leu Ala Gly Arg Asp Leu Lys Arg Leu Ala Ala Asn 
    290                 295                 300                 


Asp Leu Gln Gly Ala Ala Val Ala Thr Gly Pro Tyr His Pro Ile Trp 
305                 310                 315                 320 


Thr Gly Arg Ala Thr Asp Glu Glu Pro Leu Gly Leu Pro Lys Cys Cys 
                325                 330                 335     


Gln Pro Asp Ala Ala Asp Lys Ala 
            340                 


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic epitope

<400>  20

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic epitope

<400>  21

Asp Tyr Lys Asp Glu Asp Asp Lys 
1               5               


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic epitope

<400>  22

Ala Trp Arg His Pro Gln Phe Gly Gly 
1               5                   


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic epitope

<400>  23

Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
1               5                   10      


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic epitope

<400>  24

His His His His His His 
1               5       


<210>  25
<211>  13
<212>  PRT
<213>  Influenza virus

<400>  25

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ile Glu Gly Arg 
1               5                   10              


<210>  26
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  26

Glu Gln Lys Leu Leu Ser Glu Glu Asp Leu Asn 
1               5                   10      


<210>  27
<211>  1719
<212>  DNA
<213>  Homo sapiens

<400>  27
agcccagcca gagccgggcg gagcggagcg cgccgagcct cgtcccgcgg ccgggccggg     60

gccgggccgt agcggcggcg cctggatgcg gacccggccg cggggagacg ggcgcccgcc    120

ccgaaacgac tttcagtccc cgacgcgccc cgcccaaccc ctacgatgaa gagggcgtcc    180

gctggaggga gccggctgct ggcatgggtg ctgtggctgc aggcctggca ggtggcagcc    240

ccatgcccag gtgcctgcgt atgctacaat gagcccaagg tgacgacaag ctgcccccag    300

cagggcctgc aggctgtgcc cgtgggcatc cctgctgcca gccagcgcat cttcctgcac    360

ggcaaccgca tctcgcatgt gccagctgcc agcttccgtg cctgccgcaa cctcaccatc    420

ctgtggctgc actcgaatgt gctggcccga attgatgcgg ctgccttcac tggcctggcc    480

ctcctggagc agctggacct cagcgataat gcacagctcc ggtctgtgga ccctgccaca    540

ttccacggcc tgggccgcct acacacgctg cacctggacc gctgcggcct gcaggagctg    600

ggcccggggc tgttccgcgg cctggctgcc ctgcagtacc tctacctgca ggacaacgcg    660

ctgcaggcac tgcctgatga caccttccgc gacctgggca acctcacaca cctcttcctg    720

cacggcaacc gcatctccag cgtgcccgag cgcgccttcc gtgggctgca cagcctcgac    780

cgtctcctac tgcaccagaa ccgcgtggcc catgtgcacc cgcatgcctt ccgtgacctt    840

ggccgcctca tgacactcta tctgtttgcc aacaatctat cagcgctgcc cactgaggcc    900

ctggcccccc tgcgtgccct gcagtacctg aggctcaacg acaacccctg ggtgtgtgac    960

tgccgggcac gcccactctg ggcctggctg cagaagttcc gcggctcctc ctccgaggtg   1020

ccctgcagcc tcccgcaacg cctggctggc cgtgacctca aacgcctagc tgccaatgac   1080

ctgcagggct gcgctgtggc caccggccct taccatccca tctggaccgg cagggccacc   1140

gatgaggagc cgctggggct tcccaagtgc tgccagccag atgccgctga caaggcctca   1200

gtactggagc ctggaagacc agcttcggca ggcaatgcgc tgaagggacg cgtgccgccc   1260

ggtgacagcc cgccgggcaa cggctctggc ccacggcaca tcaatgactc accctttggg   1320

actctgcctg gctctgctga gcccccgctc actgcagtgc ggcccgaggg ctccgagcca   1380

ccagggttcc ccacctcggg ccctcgccgg aggccaggct gttcacgcaa gaaccgcacc   1440

cgcagccact gccgtctggg ccaggcaggc agcgggggtg gcgggactgg tgactcagaa   1500

ggctcaggtg ccctacccag cctcacctgc agcctcaccc ccctgggcct ggcgctggtg   1560

ctgtggacag tgcttgggcc ctgctgaccc ccagcggaca caagagcgtg ctcagcagcc   1620

aggtgtgtgt acatacgggg tctctctcca cgccgccaag ccagccgggc ggccgacccg   1680

tggggcaggc caggccaggt cctccctgat ggacgcctg                          1719


<210>  28
<211>  1422
<212>  DNA
<213>  Rattus norvegicus

<400>  28
atgaagaggg cgtcctccgg aggaagccgg ctgccgacat gggtgttatg gctacaggcc     60

tggagggtag caacgccctg ccctggtgcc tgtgtgtgct acaatgagcc caaggtcaca    120

acaagccgcc cccagcaggg cctgcaggct gtacccgctg gcatcccagc ctccagccag    180

agaatcttcc tgcacggcaa ccgaatctct tacgtgccag ccgccagctt ccagtcatgc    240

cggaatctca ccatcctgtg gctgcactca aatgcgctgg ccgggattga tgccgcggcc    300

ttcactggtc tgaccctcct ggagcaacta gatcttagtg acaatgcaca gctccgtgtc    360

gtggacccca ccacgttccg tggcctgggc cacctgcaca cgctgcacct agaccgatgc    420

ggcctgcagg agctggggcc tggcctattc cgtgggctgg cagctctgca gtacctctac    480

ctacaagaca acaacctgca ggcacttccc gacaacacct tccgagacct gggcaacctc    540

acgcatctct ttctgcatgg caaccgtatc cccagtgttc ctgagcacgc tttccgtggc    600

ttgcacagtc ttgaccgtct cctcttgcac cagaaccatg tggctcgtgt gcacccacat    660

gccttccggg accttggccg actcatgacc ctctacctgt ttgccaacaa cctctccatg    720

ctccccgcag aggtcctagt gcccctgagg tctctgcagt acctgcgact caatgacaac    780

ccctgggtgt gtgactgcag ggcacgtccg ctctgggcct ggctgcagaa gttccgaggt    840

tcctcatccg gggtgcccag caacctaccc caacgcctgg caggccgtga tctgaagcgc    900

ctggctacca gtgacttaga gggttgtgct gtggcttcgg ggcccttccg tcccttccag    960

accaatcagc tcactgatga ggagctgctg ggcctcccca agtgctgcca gccggatgct   1020

gcagacaagg cctcagtact ggaacccggg aggccggcgt ctgttggaaa tgcactcaag   1080

ggacgtgtgc ctcccggtga cactccacca ggcaatggct caggcccacg gcacatcaat   1140

gactctccat ttgggacttt gcccggctct gcagagcccc cactgactgc cctgcggcct   1200

gggggttccg agcccccggg actgcccacc acgggccccc gcaggaggcc aggttgttcc   1260

agaaagaacc gcacccgtag ccactgccgt ctgggccagg caggaagtgg gagcagtgga   1320

actggggatg cagaaggttc gggggccctg cctgccctgg cctgcagcct tgctcctctg   1380

ggccttgcac tggtactttg gacagtgctt gggccctgct ga                      1422


<210>  29
<211>  1892
<212>  DNA
<213>  Mus musculus

<400>  29
agccgcagcc cgcgagccca gcccggcccg gtagagcgga gcgccggagc ctcgtcccgc     60

ggccgggccg ggaccgggcc ggagcagcgg cgcctggatg cggacccggc cgcgcgcaga    120

cgggcgcccg ccccgaagcc gcttccagtg cccgacgcgc cccgctcgac cccgaagatg    180

aagagggcgt cctccggagg aagcaggctg ctggcatggg tgttatggct acaggcctgg    240

agggtagcaa caccatgccc tggtgcttgt gtgtgctaca atgagcccaa ggtaacaaca    300

agctgccccc agcagggtct gcaggctgtg cccactggca tcccagcctc tagccagcga    360

atcttcctgc atggcaaccg aatctctcac gtgccagctg cgagcttcca gtcatgccga    420

aatctcacta tcctgtggct gcactctaat gcgctggctc ggatcgatgc tgctgccttc    480

actggtctga ccctcctgga gcaactagat cttagtgata atgcacagct tcatgtcgtg    540

gaccctacca cgttccacgg cctgggccac ctgcacacac tgcacctaga ccgatgtggc    600

ctgcgggagc tgggtcccgg cctattccgt ggactagcag ctctgcagta cctctaccta    660

caagacaaca atctgcaggc actccctgac aacacctttc gagacctggg caacctcacg    720

catctctttc tgcatggcaa ccgtatcccc agtgtgcctg agcacgcttt ccgtggcctg    780

cacagtcttg accgcctcct cttgcaccag aaccatgtgg ctcgtgtgca cccacatgcc    840

ttccgggacc ttggccgcct catgaccctc tacctgtttg ccaacaacct ctccatgctg    900

cctgcagagg tcctaatgcc cctgaggtct ctgcagtacc tgcgactcaa tgacaacccc    960

tgggtgtgtg actgccgggc acgtccactc tgggcctggc tgcagaagtt ccgaggttcc   1020

tcatcagagg tgccctgcaa cctgccccaa cgcctggcag accgtgatct taagcgcctc   1080

gctgccagtg acctagaggg ctgtgctgtg gcttcaggac ccttccgtcc catccagacc   1140

agtcagctca ctgatgagga gctgctgagc ctccccaagt gctgccagcc agatgctgca   1200

gacaaagcct cagtactgga acccgggagg ccagcttctg ccggaaacgc cctcaaggga   1260

cgtgtgcctc ccggtgacac tccaccaggc aatggctcag gccctcggca catcaatgac   1320

tctccatttg gaactttgcc cagctctgca gagcccccac tgactgccct gcggcctggg   1380

ggttccgagc caccaggact tcccaccact ggtccccgca ggaggccagg ttgttcccgg   1440

aagaatcgca cccgcagcca ctgccgtctg ggccaggcgg gaagtggggc cagtggaaca   1500

ggggacgcag agggttcagg ggctctgcct gctctggcct gcagccttgc tcctctgggc   1560

cttgcactgg tactttggac agtgcttggg ccctgctgac cagccaccag ccaccaggtg   1620

tgtgtacata tggggtctcc ctccacgccg ccagccagag ccagggacag gctctgaggg   1680

gcaggccagg ccctccctga cagatgcctc cccaccagcc cacccccatc tccaccccat   1740

catgtttaca gggttccggg ggtggcgttt gttccagaac gccacctccc acccggatcg   1800

cggtatatag agatatgaat tttattttac ttgtgtaaaa tatcggatga cgtggaataa   1860

agagctcttt tcttaaaaaa aaaaaaaaaa aa                                 1892


<210>  30
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic general structure for an oligonucleotide used in 
       preparation of siRNA molecule


<220>
<221>  misc_feature
<222>  (1)..(200)
<223>  n is a, g, c, t, or u

<220>
<221>  misc_feature
<222>  (2)..(200)
<223>  nucleotide may be missing


<400>  30
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180

nnnnnnnnnn nnnnnnnnnn                                                200


<210>  31
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic general structure for an oligonucleotide used in 
       preparation of siRNA molecule


<220>
<221>  misc_feature
<222>  (1)..(200)
<223>  n is a, g, c, t, or u

<220>
<221>  misc_feature
<222>  (2)..(200)
<223>  nucleotide may be missing


<400>  31
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn     60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn    180

nnnnnnnnnn nnnnnnnnnn                                                200

